The GISAID Initiative benefits from substantial in-kind contributions from technical partners and commercial service providers with the common goal of strengthening the Initiative's important role in global health
QIAGEN AG, an infrastructure partner to the GISAID Initiative, provides a customized version of its annotation pipeline, adapted for full integration into EpiFlu™ v2.0 application, which is currently under development. This QIAGEN technology facilitates the quality control of all genetic sequence data in GISAID, to ensure highest data quality standards.
The Bioinformatics Institute (a member of Singapore's A*STAR's Biomedical Sciences Institutes) provides the CoVsurver and FluSurver applications under the leadership of Senior Principal Investigator Dr. Sebastian Maurer-Stroh. This tool permits the analysis of data in GISAID to highlight mutations relative to reference strains, display them in the 3D protein structure, cross-link with prior literature phenotype information, view their geographic and temporal frequency of occurrence as well as co-occurrence with other mutations.
The main application scenario for CoVsurver integrated into the EpiCoV™ database is to highlight phenotypically or epidemiologically interesting candidate mutations for further research and should ideally be combined with experimental testing and verification of any predicted phenotypes. The FluSurver has already been instrumental in the discovery of new influenza strain variants with altered antiviral susceptibility, host specificity, glycosylation and antigenic properties.
Prof. Dr. Trevor Bedford at the Fred Hutchinson Cancer Research Center in Seattle and Prof. Dr. Richard Neher at the Biozentrum University of Basel provide the next generation of TreeTool applications. This tool permits the analysis of data in GISAID, enabling users to a create phylogenetic tree for the visualization of annotated influenza phylogenies based on blab/nextflu.
The GISAID homepage was designed in collaboration with the creative team of Silke Arend at a7digital GmbH using the flexibility of open source CMS technology TYPO3 as a basis to permit the access of a wide range of content contributors commensurate with the needs of GISAID's global participation.